Rapport final
Maternal weight loss and endothelial function in her offspring: difference between prepregnancy weight loss after bariatric surgery versus intrapregnancy lifestyle intervention weight loss in obese mothers - Van De Maele Karolien
The main topic of this research revolved around a better understanding of the long-term effects on the offspring of women who underwent bariatric surgery before their pregnancy.
Therefore, a cross-sectional cohort study was designed to scrutinize the offspring of mothers who underwent bariatric surgery before pregnancy (EFFECTOR-study). They were compared to the offspring of a group of women with overweight or obesity during pregnancy (OW/OB group) and the offspring of a group of women with normal weight during pregnancy (NW group).
A prospective data collection was performed to gain insight in the body composition, metabolic and inflammatory state as well as the vascular function (measured by peripheral arterial tonometry) of the children.
The children born after bariatric surgery (BS) presented with the highest body weight SD score, BMI SD scores, excess in body fat percentage and waist circumference SD score at childhood age, compared to the matched OW/OB offspring or NW offspring. Meal-skipping behavior and fruit and vegetable consumption was comparable between the groups. We did found that the BS group consumed more low-calorie sweetened beverages compared to the NW group but less fruit juice compared to the NW and OW/OB groups. Additionally, children of the BS group had a higher diastolic blood pressure SD score and a lower Reactive Hyperemia Index compared to the children of the OW/OB and NW group.
According to the different findings, we concluded that children born after maternal surgery remain susceptible to the intergenerational, vicious circle of obesity programming.